Therapy Detail
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| Therapy Name | DSP-5336 + Gilteritinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DSP-5336 | DSP 5336|DSP5336 | MEN1-KMT2A Inhibitor 8 | DSP-5336 binds to Menin (MEN1) and inhibits its interaction with MLL (KMT2A), potentially leading to decreased growth of tumor cells harboring MLL (KMT2A) rearrangements or NPM1 mutations (Blood (2021) 138 (Supplement 1): 3339). | |
| Gilteritinib | Xospata | ASP2215 | AXL Inhibitor 30 FLT3 Inhibitor 69 | Xospata (gilteritinib) is a small molecule inhibitor of FLT3 and AXL that has activity against FLT3-ITD, FLT3 F691L, and FLT3 D835 mutations, potentially resulting in decreased tumor growth (J Clin Oncol 32:5s, 2014 (suppl; abstr 7070), PMID: 25891481). Xospata (gilteritinib) is FDA approved for use in patients with relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation (ITD, D835X, and I836X) (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04988555 | Phase Ib/II | DSP-5336 DSP-5336 + Fluconazole Azacitidine + DSP-5336 + Venetoclax DSP-5336 + Gilteritinib Azacitidine + DSP-5336 + Fluconazole + Venetoclax | A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1) | Recruiting | USA | ITA | GBR | FRA | ESP | CHE | CAN | BEL | 4 |
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