Therapy Detail
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| Therapy Name | XmAb541 + XmAb808 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| XmAb541 | XmAb-541|XmAb 541 | CD3 Antibody 125 CLDN6 Antibody 10 | XmAb541 is a bispecific antibody targeting CLDN6 and CD3 that redirects cytotoxic T-lymphocytes towards tumor cells expressing CLDN6, potentially resulting in increased tumor cell killing (J Clin Oncol 2025 43: 5_suppl, TPS652, NCI Drug Dictionary). | |
| XmAb808 | XmAb-808|XmAb 808 | CD276 Antibody 24 CD28 Antibody 14 | XmAb808 is a bispecific antibody that targets CD276 (B7-H3) on tumor cells and CD28 expressed on T-lymphocytes, which potentially leads to enhanced antitumor immune response (Journal for ImmunoTherapy of Cancer 2023;11). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07593092 | Phase I | XmAb541 + XmAb808 | Phase 1, Safety and Tolerability Study of XmAb541 and XmAb808 in Advanced Solid Tumors | Not yet recruiting | USA | 0 |
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