Therapy Detail
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| Therapy Name | Cisplatin + EP0031 + Pemetrexed Disodium |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cisplatin | Platinol | CDDP | Chemotherapy - Platinum 7 | Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary). |
| EP0031 | EP-0031|EP 0031|A400|A-400|A 400|KL590586|Lunbotinib | RET Inhibitor 53 | EP0031 inhibits RET, potentially leading to decreased growth of tumors expressing RET fusions and mutations, and resulting in antitumor activity (NCI Drug Dictionary, J Clin Oncol 41, 2023 (suppl 16; abstr 3007)). | |
| Pemetrexed Disodium | Alimta | LY231514|Ciambra|pemetrexed | Chemotherapy - Antimetabolite 14 | Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05443126 | Phase Ib/II | Carboplatin + EP0031 + Pemetrexed Disodium Cisplatin + EP0031 + Pemetrexed Disodium | A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies | Recruiting | USA | POL | ITA | GBR | FRA | ESP | DEU | 1 |
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