Therapy Detail
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| Therapy Name | Darolutamide + ORIC-944 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Darolutamide | Nubeqa | BAY1841788|ODM-201 | Hormone - Anti-androgens 59 | Nubeqa (darolutamide) is an androgen receptor antagonist that binds to and prevents nuclear translocation of the androgen receptor, thereby inhibiting expression of genes downstream of androgen receptor signaling that regulate proliferation of prostate cancer cells (PMID: 28490267). Nubeqa (darolutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer, and as monotherapy or in combination with docetaxel in patients with metastatic hormone-sensitive prostate cancer (FDA.gov). |
| ORIC-944 | ORIC 944|ORIC944|Rinzimetostat|MRTX-2219|MRTX 2219|MRTX2219 | ORIC-944 inhibits PRC2 through binding to its EED subunit, potentially leading to decreased cell proliferation and inhibition of tumor growth (Cancer Res 2021;81(13_Suppl):Abstract nr 1131). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07723248 | Phase III | Enzalutamide Docetaxel Darolutamide Darolutamide + ORIC-944 | A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1) (Himalayas-1) | Recruiting | USA | 0 |
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