Therapy Detail
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| Therapy Name | Dexamethasone + Mercaptopurine + Pegaspargase + Vincristine Sulfate |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Dexamethasone | Adexone | Desametasone | ||
| Mercaptopurine | Purixan | 6 MP|Purinethol | ||
| Pegaspargase | Oncaspar | PEG-asparaginase|PEG-ASP | Oncaspar (pegaspargase) is a pegylated version of L-asparaginase, which converts L-asparagine to ammonia and L-aspartic acid, reducing available asparagine resulting in decreased protein synthesis, inhibition of tumor cell proliferation, and increased apoptosis (NCI Drug Dictionary). | |
| Vincristine Sulfate | Oncovin | 22-Oxovincaleukoblastine|vincristine | Oncovin (vincristine) binds microtubules and prevents mitotic spindle formation, resulting in cell-cycle arrest (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07227584 | Phase II | Dexamethasone + Mercaptopurine + Methotrexate + Vincristine Sulfate Blinatumomab + Dexamethasone Cytarabine + Dexamethasone Cytarabine + Dexamethasone + Etoposide + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Dexamethasone + Doxorubicin + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Dexamethasone + Mercaptopurine + Pegaspargase + Vincristine Sulfate Cyclophosphamide + Cytarabine + Mercaptopurine Dexamethasone + Doxorubicin + Pegaspargase + Vincristine Sulfate | ALL Backbone in AYAs | Recruiting | USA | 0 |
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