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Drug Name Pegaspargase
Trade Name Oncaspar
Synonyms PEG-asparaginase|PEG-ASP
Drug Descriptions

Oncaspar (pegaspargase) is a pegylated version of L-asparaginase, which converts L-asparagine to ammonia and L-aspartic acid, reducing available asparagine resulting in decreased protein synthesis, inhibition of tumor cell proliferation, and increased apoptosis (NCI Drug Dictionary).

DrugClasses
CAS Registry Number 130167-69-0
NCIT ID C1200

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Blinatumomab + Cyclophosphamide + Cytarabine + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Blinatumomab Cyclophosphamide Cytarabine Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 1
Bortezomib + Cyclophosphamide + Cytarabine + Dexamethasone + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Bortezomib Cyclophosphamide Cytarabine Dexamethasone Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Bortezomib + Cyclophosphamide + Cytarabine + Dexamethasone + Mercaptopurine + Pegaspargase + Vincristine Sulfate Bortezomib Cyclophosphamide Cytarabine Dexamethasone Mercaptopurine Pegaspargase Vincristine Sulfate 0 0
Bortezomib + Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Vincristine Sulfate Bortezomib Dexamethasone Doxorubicin Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Dexamethasone + Etoposide + Ifosfamide + Methotrexate + Pegaspargase + Vincristine Sulfate + Vindesine Cyclophosphamide Cytarabine Daunorubicin Dexamethasone Etoposide Ifosfamide Methotrexate Pegaspargase Vincristine Sulfate Vindesine 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Imatinib + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Rituximab + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Imatinib Melphalan Mercaptopurine Methotrexate Pegaspargase Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Imatinib + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Imatinib Melphalan Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Melphalan + Mercaptopurine + Methotrexate + Nelarabine + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Melphalan Mercaptopurine Methotrexate Nelarabine Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Melphalan Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Mercaptopurine + Methotrexate + Pegaspargase + Prednisone + Venetoclax + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Mercaptopurine Methotrexate Pegaspargase Prednisone Venetoclax Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Thioguanine Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Vincristine Sulfate 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Pegaspargase Thioguanine Vincristine Sulfate 0 2
Cyclophosphamide + Cytarabine + Dexamethasone + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Doxorubicin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Sulfate Cyclophosphamide Cytarabine Doxorubicin Methotrexate Pegaspargase Thioguanine Vincristine Sulfate 0 0
Cyclophosphamide + Cytarabine + Leucovorin + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Leucovorin Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Pegaspargase + Ruxolitinib + Vincristine Sulfate Cyclophosphamide Cytarabine Mercaptopurine Methotrexate Pegaspargase Ruxolitinib Vincristine Sulfate 0 0
Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 2
Cyclophosphamide + Cytarabine + Mercaptopurine + Pegaspargase Cyclophosphamide Cytarabine Mercaptopurine Pegaspargase 0 1
Cyclophosphamide + Cytarabine + Mercaptopurine + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Mercaptopurine Pegaspargase Vincristine Sulfate 0 0
Cyclophosphamide + Cytarabine + Methotrexate + Pegaspargase + Thioguanine + Vincristine Sulfate Cyclophosphamide Cytarabine Methotrexate Pegaspargase Thioguanine Vincristine Sulfate 0 1
Cyclophosphamide + Daunorubicin + Pegaspargase + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Daunorubicin Pegaspargase Prednisone Rituximab Vincristine Sulfate 0 0
Cyclophosphamide + Dexamethasone + Doxorubicin + Nelarabine + Pegaspargase + Venetoclax + Vincristine Sulfate Cyclophosphamide Dexamethasone Doxorubicin Nelarabine Pegaspargase Venetoclax Vincristine Sulfate 0 1
Cyclophosphamide + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Methotrexate Pegaspargase Vincristine Sulfate 0 2
Cyclophosphamide + Pegaspargase + Vincristine Sulfate Cyclophosphamide Pegaspargase Vincristine Sulfate 0 0
Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Cytarabine Dasatinib Dexamethasone Hydrocortisone Leucovorin Methotrexate Navitoclax Pegaspargase Venetoclax Vincristine Sulfate 0 1
Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Cytarabine Dasatinib Dexamethasone Hydrocortisone Methotrexate Navitoclax Pegaspargase Venetoclax 0 1
Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Methotrexate + Pegaspargase + Prednisolone + Vincristine Sulfate Cytarabine Daunorubicin Dexamethasone Hydrocortisone Methotrexate Pegaspargase Prednisolone Vincristine Sulfate 0 1
Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Pegaspargase + Thioguanine + Vincristine sulfate liposome Cytarabine Daunorubicin Dexamethasone Hydrocortisone Pegaspargase Thioguanine Vincristine sulfate liposome 0 1
Cytarabine + Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Cytarabine Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Pegaspargase Prednisone Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Methotrexate + Pegaspargase + Prednisolone + Vincristine Sulfate Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisolone Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Doxorubicin + Hydrocortisone Sodium Succinate + Methotrexate + Pegaspargase + Vincristine Sulfate Cytarabine Dexamethasone Doxorubicin Hydrocortisone Sodium Succinate Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Fludarabine + JNJ-75276617 + Pegaspargase + Vincristine Sulfate Cytarabine Dexamethasone Fludarabine JNJ-75276617 Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Cytarabine Dexamethasone Hydrocortisone Leucovorin Methotrexate Navitoclax Pegaspargase Venetoclax Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Cytarabine Dexamethasone Hydrocortisone Methotrexate Navitoclax Pegaspargase Venetoclax 0 1
Cytarabine + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Cytarabine Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Pegaspargase + Vincristine Sulfate Cytarabine Dexamethasone Pegaspargase Vincristine Sulfate 0 0
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisolone + Vincristine Sulfate Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisolone Vincristine Sulfate 0 1
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisone Vincristine Sulfate 0 1
Cytarabine + Hydrocortisone + Leucovorin + Mercaptopurine + Pegaspargase Cytarabine Hydrocortisone Leucovorin Mercaptopurine Pegaspargase 0 1
Cytarabine + Leucovorin + Methotrexate + Pegaspargase + Vincristine Sulfate Cytarabine Leucovorin Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cytarabine + Methotrexate + Nelarabine + Pegaspargase + Venetoclax Cytarabine Methotrexate Nelarabine Pegaspargase Venetoclax 0 1
Dasatinib + Dexamethasone + Pegaspargase + Vincristine Sulfate Dasatinib Dexamethasone Pegaspargase Vincristine Sulfate 0 1
Daunorubicin + Dexamethasone + Imatinib + Pegaspargase + Vincristine Sulfate Daunorubicin Dexamethasone Imatinib Pegaspargase Vincristine Sulfate 0 0
Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 2
Daunorubicin + Inotuzumab ozogamicin + Pegaspargase + Prednisone + Vincristine Sulfate Daunorubicin Inotuzumab ozogamicin Pegaspargase Prednisone Vincristine Sulfate 0 1
Daunorubicin + Methotrexate + Pegaspargase + Prednisolone + Vincristine Sulfate Daunorubicin Methotrexate Pegaspargase Prednisolone Vincristine Sulfate 0 1
Daunorubicin + Pegaspargase + Prednisone + Rituximab + Vincristine Sulfate Daunorubicin Pegaspargase Prednisone Rituximab Vincristine Sulfate 0 0
Daunorubicin + Pegaspargase + Vincristine Sulfate Daunorubicin Pegaspargase Vincristine Sulfate 0 1
Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Vincristine Sulfate Dexamethasone Doxorubicin Methotrexate Pegaspargase Vincristine Sulfate 0 2
Dexamethasone + Doxorubicin + MLN4924 + Pegaspargase + Vincristine Sulfate Dexamethasone Doxorubicin MLN4924 Pegaspargase Vincristine Sulfate 0 1
Dexamethasone + Doxorubicin + Pegaspargase + Vincristine Sulfate Dexamethasone Doxorubicin Pegaspargase Vincristine Sulfate 0 2
Dexamethasone + Methotrexate + Mitoxantrone + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Mitoxantrone Pegaspargase Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Pegaspargase Vincristine sulfate liposome 0 1
Dexamethasone + Pegaspargase + Vincristine Sulfate Dexamethasone Pegaspargase Vincristine Sulfate 0 2
Leucovorin + Pegaspargase + Vincristine Sulfate Leucovorin Pegaspargase Vincristine Sulfate 0 1
Methotrexate + Pegaspargase Methotrexate Pegaspargase 0 1
Methotrexate + Pegaspargase + Venetoclax Methotrexate Pegaspargase Venetoclax 0 1
Methotrexate + Pegaspargase + Vincristine Sulfate Methotrexate Pegaspargase Vincristine Sulfate 0 2
Nelarabine + Pegaspargase Nelarabine Pegaspargase 0 1
Nelarabine + Pegaspargase + Venetoclax Nelarabine Pegaspargase Venetoclax 0 1
Pegaspargase Pegaspargase 0 16
Pegaspargase + Prednisolone + Vincristine Sulfate Pegaspargase Prednisolone Vincristine Sulfate 0 1
Pegaspargase + Prednisone + Vincristine Sulfate Pegaspargase Prednisone Vincristine Sulfate 0 1


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