Therapy Detail
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| Therapy Name | ABBV-453 + Etentamig |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ABBV-453 | ABBV 453|ABBV453|Surzetoclax | BCL2 inhibitor 29 | ABBV-453 inhibits BCL2, potentially leading to increased tumor cell apoptosis (NCI Drug Dictionary). | |
| Etentamig | TNB-383B|TNB383B|TNB 383B|ABBV383|ABBV 383|ABBV-383 | CD3 Antibody 128 TNFRSF17 Antibody 22 | Etentamig (ABBV-383) is a bispecific antibody that targets alpha CD3 and BCMA, potentially resulting in the activation of T-cells and tumor cell lysis (Journal of Clinical Oncology 2018 36:15_suppl, 8034-8034, PMID: 36029527). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06953960 | Phase Ib/II | ABBV-453 + Daratumumab + Dexamethasone ABBV-453 ABBV-453 + Etentamig Daratumumab + Dexamethasone + Pomalidomide | A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM) | Recruiting | USA | SWE | POL | ITA | ISR | GBR | FRA | DEU | BEL | AUS | 2 |
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