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Therapy Name	Histrelin acetate
Synonyms
Therapy Description	Histrelin acetate is an analog of gonadotropin-releasing hormone (GnRH), which binds to and activates GnRH receptors, resulting in reduced testosterone production in males, and thus may inhibit growth of androgen-receptor positive tumors (NCI Drug Dictionary).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Histrelin acetate	Vantas	Supprelin		Histrelin acetate is an analog of gonadotropin-releasing hormone (GnRH), which binds to and activates GnRH receptors, resulting in reduced testosterone production in males, and thus may inhibit growth of androgen-receptor positive tumors (NCI Drug Dictionary).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT02278185	Phase II	Goserelin Degarelix Histrelin acetate Triptorelin Leuprolide Enzalutamide	Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate Cancer	Completed	USA	0
NCT03678025	Phase III	Docetaxel Nilutamide Triptorelin Bicalutamide Leuprolide Degarelix Goserelin Flutamide Prednisone Abiraterone Histrelin acetate	Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer	Recruiting	USA \| CHE	3
NCT04787744	Phase II	Goserelin Degarelix Relugolix Nilutamide Triptorelin Histrelin acetate Docetaxel + Prednisone Leuprolide Apalutamide Abiraterone + Prednisone Flutamide Abiraterone + Methylprednisolone Bicalutamide Docetaxel Enzalutamide	Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer (VA STARPORT)	Recruiting	USA	0
NCT05050084	Phase III	Buserelin Relugolix Degarelix Goserelin Leuprolide Histrelin acetate Triptorelin Darolutamide + Goserelin Bicalutamide Darolutamide + Degarelix Darolutamide + Leuprolide Darolutamide + Triptorelin Buserelin + Darolutamide Darolutamide + Histrelin acetate Flutamide Darolutamide + Relugolix	Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score	Recruiting	USA \| CAN	0
NCT06378866	Phase II	Degarelix Goserelin Darolutamide Relugolix Triptorelin Enzalutamide Histrelin acetate Abiraterone + Prednisone Leuprolide Apalutamide	Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial (DIVINE)	Recruiting	USA	0

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