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Therapy Name Azer-cel + Ibrutinib + Interleukin-12
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Azer-cel azercabtagene zapreleucel CD19 Immune Cell Therapy 78 Azer-cel (azercabtagene zapreleucel) is an allogeneic chimeric antigen receptor T-cell (CAR-T) therapy comprising healthy donor T-cells engineered to express a chimeric antigen receptor (CAR) that targets CD19, which may lead to anti-tumor immune response against CD19-expressing tumor cells (J Clin Oncol 44 (16_suppl):7012).
Ibrutinib Imbruvica PCI-32765 BTK inhibitor 39 EGFR Inhibitor (Pan) 63 HER2 Inhibitor 45 Imbruvica (ibrutinib) is a selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK), which promotes apoptosis and inhibits B-cell mediated signaling pathways, and has additional activity against ERBB2 (HER2) and EGFR (PMID: 20615965, PMID: 21422473, PMID: 27678331). Imbruvica (Ibrutinib) is FDA approved for use in patients with CLL/SLL and CLL/SLL with del 17p, and Waldenstroem’s macroglobulinemia (FDA.gov).
Interleukin-12 Ro 24-7472|NM-IL-12|Edodekin alfa Interleukin-12 (NM-IL-12) is a recombinant version of Interleukin-12 (IL-12), which may decrease tumor angiogenesis (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03666000 Phase I Azer-cel + Interleukin-12 + Pirtobrutinib Azer-cel + Ibrutinib + Interleukin-12 Azer-cel + Interleukin-12 Azer-cel + Interleukin-12 + Zanubrutinib Acalabrutinib + Azer-cel + Interleukin-12 Cyclophosphamide + Fludarabine Azer-cel Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL) Recruiting USA | AUS 0


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