Therapy Detail
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| Therapy Name | Gemcitabine + JNJ-95566692 + Oxaliplatin + Rituximab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Gemcitabine | Gemzar | Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 | Chemotherapy - Antimetabolite 14 | Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). |
| JNJ-95566692 | JNJ95566692|JNJ 95566692 | CD20 Antibody 29 CD3 Antibody 128 | Limited information is currently available on JNJ-95566692, a putative trispecific antibody targeting CD79b, MS4A1 (CD20), and CD3 (Feb 2026). | |
| Oxaliplatin | Eloxatin | Diaminocyclohexane Oxalatoplatinum | Chemotherapy - Platinum 7 | Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity, and is FDA approved for colorectal cancer (FDA.gov). |
| Rituximab | Rituxan | IDEC-C2B8|MabThera | CD20 Antibody 29 | Rituxan (rituximab) is a chimeric mononclonal antibody that binds to CD20 on B-cells, resulting in induction of complement-dependent and antibody-dependent cytotoxicity, and potentially leading to decreased B-cell tumor growth (PMID: 28983798). Rituxan (rituximab) is FDA approved for use as monotherapy or in combination with chemotherapy in CD20-positive B-cell non-Hodgkin lymphoma, in combination with fludarabine and cyclophosphamide in CD20-positive chronic lymphocytic leukemia, and in combination with chemotherapy in pediatric patients (6 month to 18 years of age) with treatment-naive, CD20-positive diffuse large B-cell lymphoma, Burkitt lymphoma, Burkitt-like lymphoma, or mature B-cell acute leukemia (B-AL) (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07308132 | Phase I | Cyclophosphamide + Doxorubicin + JNJ-95566692 + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide + Doxorubicin + JNJ-87801493 + JNJ-95566692 + Prednisone + Vincristine Sulfate Cyclophosphamide + Doxorubicin + JNJ-95566692 + Prednisone + Rituximab + Vincristine Sulfate JNJ-87801493 + JNJ-95566692 + Lenalidomide JNJ-95566692 + Lenalidomide Gemcitabine + JNJ-87801493 + JNJ-95566692 + Oxaliplatin + Rituximab Gemcitabine + JNJ-95566692 + Oxaliplatin + Rituximab JNJ-87801493 + JNJ-95566692 + Loncastuximab tesirine-lpyl JNJ-95566692 + Loncastuximab tesirine-lpyl JNJ-87801493 JNJ-87801493 + JNJ-95566692 JNJ-95566692 Cyclophosphamide + Doxorubicin + JNJ-87801493 + JNJ-95566692 + Polatuzumab vedotin-piiq + Prednisone + Rituximab | A Study of JNJ-95566692 in Participants With Non-Hodgkin Lymphoid Malignancies | Recruiting | TUR | FRA | ESP | BEL | AUS | 0 |
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