Therapy Detail
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| Therapy Name | Bevacizumab + Spevatamig + Trifluridine-tipiracil hydrochloride |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 17 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| Spevatamig | PT-886|PT 886|PT886 | CD47 Antibody 31 CLDN18.2 Antibody 26 | Spevatamig (PT-886) is a bispecific antibody that targets CLDN18.2 and CD47, which potentially results in increased tumor cell killing and decreased tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 4260). | |
| Trifluridine-tipiracil hydrochloride | Lonsurf | TAS-102|TAS102|TAS 102|S 95005|S95005|S-95005 | Lonsurf (trifluridine/tipiracil hydrochloride) is an oral combination comprised of TFT and a thymidine phosphorylase inhibitor, which can result in DNA fragmentation thereby preventing angiogenesis and tumor growth (PMID: 29226002). Lonsurf (trifluridine/tipiracil hydrochloride) is FDA-approved for use in patients with colorectal cancer, gastric or gastroesophageal junction adenocarcinoma, and in combination with Avastin (bevacizumab) in patients with previously-treated metastatic colorectal cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05482893 | Phase Ib/II | Capecitabine + Oxaliplatin + Pembrolizumab + Spevatamig Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab + Spevatamig Pembrolizumab + Spevatamig Spevatamig Fluorouracil + Leucovorin + Oxaliplatin + Spevatamig Fluorouracil + Gemcitabine + Irinotecan + Leucovorin + Oxaliplatin + Spevatamig Gemcitabine + Nab-paclitaxel + Spevatamig Paclitaxel + Spevatamig Bevacizumab + Spevatamig + Trifluridine-tipiracil hydrochloride Bevacizumab + Spevatamig Spevatamig + Trifluridine-tipiracil hydrochloride | Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, for the Treatment of Patients With Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study) | Recruiting | USA | 0 |
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