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Drug Name | Trifluridine-tipiracil hydrochloride |
Trade Name | Lonsurf |
Synonyms | TAS-102|TAS102|TAS 102|S 95005|S95005|S-95005 |
Drug Descriptions |
Lonsurf (trifluridine/tipiracil hydrochloride) is an oral combination comprised of TFT and a thymidine phosphorylase inhibitor, which can result in DNA fragmentation thereby preventing angiogenesis and tumor growth (PMID: 29226002). Lonsurf (trifluridine/tipiracil hydrochloride) is FDA-approved for use in patients with colorectal cancer, gastric or gastroesophageal junction adenocarcinoma, and in combination with Avastin (bevacizumab) in patients with previously-treated metastatic colorectal cancer (FDA.gov). |
DrugClasses | |
CAS Registry Number | 183204-74-2 |
NCIT ID | C102554 |