Therapy Detail
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| Therapy Name | FHD-286 + Gilteritinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| FHD-286 | FHD286|FHD 286 | FHD-286 inhibits SMARCA4 (BRG1) and SMARCA2 (BRM), which may lead to altered chromatin accessibility and decreased tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr ND14, PMID: 38437498). | ||
| Gilteritinib | Xospata | ASP2215 | AXL Inhibitor 30 FLT3 Inhibitor 69 | Xospata (gilteritinib) is a small molecule inhibitor of FLT3 and AXL that has activity against FLT3-ITD, FLT3 F691L, and FLT3 D835 mutations, potentially resulting in decreased tumor growth (J Clin Oncol 32:5s, 2014 (suppl; abstr 7070), PMID: 25891481). Xospata (gilteritinib) is FDA approved for use in patients with relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation (ITD, D835X, and I836X) (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KMT2A rearrange FLT3 exon 14 ins FLT3 D835Y | acute myeloid leukemia | sensitive | FHD-286 + Gilteritinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, FHD-286 and Xospata (gilteritinib) synergistically inhibited viability in acute myeloid leukemia cells harboring a KMT2A rearrangement, FLT3-ITD and FLT3 D835Y in culture, and resulted in greater reduction of tumor burden and increased survival compared to either agent alone in a cell line xenograft model (PMID: 40089460). | 40089460 |
| KMT2A rearrange FLT3 exon 14 ins | acute myeloid leukemia | sensitive | FHD-286 + Gilteritinib | Preclinical - Cell culture | Actionable | In a preclinical study, FHD-286 and Xospata (gilteritinib) synergistically inhibited viability in acute myeloid leukemia cells harboring a KMT2A rearrangement and FLT3-ITD in culture (PMID: 40089460). | 40089460 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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