Therapy Detail
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| Therapy Name | Mirvetuximab Soravtansine + PHST001 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Mirvetuximab Soravtansine | Elahere | IMGN853|M9346A-sulfo-SPDB-DM4|mirvetuximab soravtansine-gynx | FOLR1-targeted Therapy 26 | Elahere (mirvetuximab soravtansine) is an antibody-drug conjugate comprised of an antibody directed against FOLR1 linked to the tubulin polymerization-inhibiting drug DM4, leading to cell death in Folr1-expressing tumors (PMID: 26136852, PMID: 25904506). Elahere (mirvetuximab soravtansine) is FDA approved for use in patients with FOLR1-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatments (FDA.gov). |
| PHST001 | PHST 001|PHST-001 | CD24 Antibody 4 | PHST001 is a monoclonal antibody targeting CD24, which potentially induces macrophage-dependent tumor cell phagocytosis and inhibits tumor growth (Journal for ImmunoTherapy of Cancer 2024;12). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06840886 | Phase I | Mirvetuximab Soravtansine PHST001 Doxorubicin + PHST001 Fluorouracil + Irinotecan + Leucovorin + PHST001 Fluorouracil + Leucovorin + Oxaliplatin + PHST001 Gemcitabine + PHST001 Paclitaxel + PHST001 PHST001 + Topotecan Mirvetuximab Soravtansine + PHST001 PHST001 + Trastuzumab deruxtecan | A Study of PHST001 in Advanced Solid Tumors | Recruiting | USA | 0 |
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