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Therapy Detail
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| Therapy Name | O6-benzylguanine |
| Synonyms | |
| Therapy Description |
O6-benzylguanine is a guanine analogue that binds and inhibits O6-alkylguanine-DNA alkyltransferase (AGT), thereby inhibiting DNA repair (PMID: 9815757, PMID: 25407559). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| O6-benzylguanine | O6-BG|NSC-637037 | O6-benzylguanine is a guanine analogue that binds and inhibits O6-alkylguanine-DNA alkyltransferase (AGT), thereby inhibiting DNA repair (PMID: 9815757, PMID: 25407559). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02343666 | Phase I | Filgrastim Carmustine Plerixafor O6-benzylguanine | HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection | Withdrawn | USA | 0 |
| NCT00669669 | Phase Ib/II | O6-benzylguanine Carmustine + Filgrastim + Plerixafor + Temozolomide | Dose-Intensive Chemotherapy in Combination With Chemoprotected Autologous Stem Cells in Treating Patients With Malignant Gliomas | Terminated | USA | 0 |
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