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Drug Name | O6-benzylguanine |
Trade Name | |
Synonyms | O6-BG|NSC-637037 |
Drug Descriptions |
O6-benzylguanine is a guanine analogue that binds and inhibits O6-alkylguanine-DNA alkyltransferase (AGT), thereby inhibiting DNA repair (PMID: 9815757, PMID: 25407559). |
DrugClasses | |
CAS Registry Number | 19916-73-5 |
NCIT ID | C1306 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carmustine + Filgrastim + O6-benzylguanine + Temozolomide | Carmustine Filgrastim O6-benzylguanine Temozolomide | 0 | 1 |
O6-benzylguanine | O6-benzylguanine | 0 | 2 |
O6-benzylguanine + Temozolomide | O6-benzylguanine Temozolomide | 0 | 1 |