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Therapy Name ASP-1929
Synonyms
Therapy Description

ASP1929 (RM-1929) is comprised of the EGFR antibody cetuximab conjugated to the dye IR700, which binds to EGFR-expressing cells and disrupts the cell membrane upon exposure to near-infared light, and may induce antitumor activity (NCI Drug Dictionary, J Clin Oncol 42, 2024 (suppl 16; abstr 6083)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ASP-1929 Cetuximab sarotalocan|Cetuximab-IRDye-700DX|RM-1929|Cet-IR700|ASP1929 EGFR Antibody 60 ASP1929 (RM-1929) is comprised of the EGFR antibody cetuximab conjugated to the dye IR700, which binds to EGFR-expressing cells and disrupts the cell membrane upon exposure to near-infared light, and may induce antitumor activity (NCI Drug Dictionary, J Clin Oncol 42, 2024 (suppl 16; abstr 6083)).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02422979 Phase I ASP-1929 Study of RM-1929 and Photoimmunotherapy in Patients With Recurrent Head and Neck Cancer Completed USA 0
NCT03769506 Phase III Methotrexate Cetuximab ASP-1929 Docetaxel Paclitaxel ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy Recruiting USA 3


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