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Therapy Name Vofatamab
Synonyms
Therapy Description

Vofatamab (B-701) is a monoclonal antibody, which binds FGFR3 to prevent phosphorylation and signaling, thereby inhibiting proliferation and promoting apoptosis in cancer cells (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 4534-4534, PMID: 22203368).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Vofatamab B-701|MFGR1877S|RG-7444|R3Mab FGFR3 Antibody 4 Vofatamab (B-701) is a monoclonal antibody, which binds FGFR3 to prevent phosphorylation and signaling, thereby inhibiting proliferation and promoting apoptosis in cancer cells (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 4534-4534, PMID: 22203368).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 R248C Advanced Solid Tumor sensitive Vofatamab Preclinical - Cell culture Actionable In a preclinical study, Vofatamab (B-701) inhibited ligand-independent proliferation induced by FGFR3 R248C in cultured cells (PMID: 19381019). 19381019
FGFR3 over exp multiple myeloma sensitive Vofatamab Phase I Actionable In a Phase I trial, Vofatamab (B-701) demonstrated safety and resulted in stable disease in 42% (6/14) of multiple myeloma patients overexpressing FGFR3 (Blood (ASH Annual Meeting Abstracts) 2012 120: Abstract 4029). detail...
FGFR3 wild-type bladder carcinoma sensitive Vofatamab Preclinical - Cell line xenograft Actionable In a preclinical study, Vofatamab (B-701) decreased wild-type FGFR3 activation, thereby inhibited cell proliferation of FGFR3 wild-type human bladder cancer cells in culture and in cell line xenograft models (PMID: 19381019). 19381019
FGFR3 K652E Advanced Solid Tumor sensitive Vofatamab Preclinical - Cell culture Actionable In a preclinical study, Vofatamab (B-701) inhibited ligand-dependent cell proliferation in cells expressing FGFR3 K652E in culture (PMID: 19381019). 19381019
FGFR3 S249C Advanced Solid Tumor sensitive Vofatamab Preclinical - Cell culture Actionable In a preclinical study, Vofatamab (B-701) inhibited proliferation of transformed cells expressing FGFR3 S249C in culture (PMID: 19381019). 19381019
FGFR3 Y375C Advanced Solid Tumor sensitive Vofatamab Preclinical - Cell culture Actionable In a preclinical study, Vofatamab (B-701) inhibited ligand-dependent proliferation of cells expressing FGFR3 Y375C in culture (PMID: 19381019). 19381019
FGFR3 G372C Advanced Solid Tumor sensitive Vofatamab Preclinical - Cell culture Actionable In a preclinical study, Vofatamab (B-701) inhibited ligand-dependent proliferation in cells expressing FGFR3 G372C (PMID: 19381019). 19381019
FGFR3 S249C bladder carcinoma sensitive Vofatamab Preclinical - Cell line xenograft Actionable In a preclinical study, Vofatamab (B-701) decreased dimer formation and constitutive activation of FGFR3 S249C, and inhibited growth of bladder cancer cell lines harboring FGFR3 S249C in culture and in xenograft models (PMID: 19381019). 19381019

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02401542 Phase Ib/II Docetaxel + Vofatamab Vofatamab Docetaxel Dose Escalation, Expansion Study of Vofatamab (B-701) in Treatment of Locally Advanced or Metastatic Urothelial Cell Carcinoma (FIERCE-21) Terminated USA | TUR | SWE | ITA | GBR | ESP | CZE 2


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