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Therapy Name Tirapazamine
Synonyms
Therapy Description

Tirazone (tirapazamine) is a hypoxia-activated prodrug that induces DNA damage within hypoxic regions of tumors, potentially providing antineoplastic activity (PMID: 18666379, PMID: 32543771).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tirapazamine Tirazone SR4233|WIN 59075 Tirazone (tirapazamine) is a hypoxia-activated prodrug that induces DNA damage within hypoxic regions of tumors, potentially providing antineoplastic activity (PMID: 18666379, PMID: 32543771).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02174549 Phase I Tirapazamine Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer Active, not recruiting USA 0
NCT03145558 Phase II Doxorubicin Tirapazamine TATE Versus TACE in Intermediate Stage HCC (TATE) Suspended USA 0


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