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Therapy Name	NSC59984
Synonyms
Therapy Description	NSC59984 is a small molecule that both induces degradation of mutant Tp53 and reactivates Tp53 pathway signaling through Tp73, which may result in increased cell death in Tp53-mutant tumor cells (PMID: 26294215, PMID: 30667081).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
NSC59984		NSC 59984	p53 Activator 11	NSC59984 is a small molecule that both induces degradation of mutant Tp53 and reactivates Tp53 pathway signaling through Tp73, which may result in increased cell death in Tp53-mutant tumor cells (PMID: 26294215, PMID: 30667081).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TP53 mutant	colorectal cancer	predicted - sensitive	NSC59984	Preclinical - Cell line xenograft	Actionable	In a preclinical study, NSC59984 treatment resulted in increased Tp53 signaling and cell death in colorectal cancer cell lines harboring TP53 mutations, and inhibited tumor growth in TP53-mutant cell line colorectal cancer xenograft models (PMID: 26294215).	26294215
TP53 R175H	colorectal cancer	sensitive	NSC59984	Preclinical - Cell culture	Actionable	In a preclinical study, treatment with NSC59984 resulted in increased degradation of mutant Tp53 and cell death in a colorectal cancer cell line harboring TP53 R175H in culture (PMID: 26294215).	26294215
TP53 R175L	colorectal cancer	sensitive	NSC59984	Preclinical - Cell culture	Actionable	In a preclinical study, treatment with NSC59984 resulted in increased degradation of mutant Tp53 and cell death in a colorectal cancer cell line harboring TP53 R175L in culture (PMID: 26294215).	26294215
TP53 R273H TP53 P309S	colorectal cancer	sensitive	NSC59984	Preclinical - Cell culture	Actionable	In a preclinical study, treatment with NSC59984 induced Tp53 pathway signaling, degradation of mutant Tp53, and cell death in a colorectal cancer cell line harboring TP53 R273H and TP53 P309S in culture (PMID: 26294215).	26294215

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