NSC59984
Drug Detail
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| Drug Name | NSC59984 |
| Trade Name | |
| Synonyms | NSC 59984 |
| Drug Descriptions |
NSC59984 is a small molecule that both induces degradation of mutant Tp53 and reactivates Tp53 pathway signaling through Tp73, which may result in increased cell death in Tp53-mutant tumor cells (PMID: 26294215, PMID: 30667081). |
| DrugClasses | p53 Activator 12 |
| CAS Registry Number | 803647-40-7 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cisplatin + NSC59984 | Cisplatin NSC59984 | 1 | 0 |
| NSC59984 | NSC59984 | 4 | 0 |
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