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Drug Name | NSC59984 |
Trade Name | |
Synonyms | NSC 59984 |
Drug Descriptions |
NSC59984 is a small molecule that both induces degradation of mutant Tp53 and reactivates Tp53 pathway signaling through Tp73, which may result in increased cell death in Tp53-mutant tumor cells (PMID: 26294215, PMID: 30667081). |
DrugClasses | p53 Activator 11 |
CAS Registry Number | 803647-40-7 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cisplatin + NSC59984 | Cisplatin NSC59984 | 1 | 0 |
NSC59984 | NSC59984 | 4 | 0 |