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Therapy Name ETC-159
Synonyms
Therapy Description

ETC-159 is a small molecule inhibitor of PORCN, which is demonstrated to suppress Wnt signaling and may result in inhibition of cell growth and lead to upregulation of genes related to cell differentiation (PMID: 26257057, PMID: 31391551).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ETC-159 ETC-1922159 WNT Inhibitor 16 ETC-159 is a small molecule inhibitor of PORCN, which is demonstrated to suppress Wnt signaling and may result in inhibition of cell growth and lead to upregulation of genes related to cell differentiation (PMID: 26257057, PMID: 31391551).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02521844 Phase I ETC-159 A Study to Evaluate the Safety and Tolerability of ETC-1922159 in Advanced Solid Tumours Active, not recruiting USA 1


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