Therapy Detail
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| Therapy Name | Exemestane + GS-5829 |
| Synonyms | |
| Therapy Description |
Limited information is currently available GS-5829, a putative BET inhibitor (Jun, 2016). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Exemestane | Aromasin | Aromatase Inhibitor 3 | Aromasin (exemestane) is an aromatase inhibitor, which prevents the conversion of androgenic precursors to estrogens (NCI Drug Dictionary). | |
| GS-5829 | Alobresib|GS5829|GS 5829 | BET Inhibitor (Pan) 32 | Alobresib (GS-5829) is a BET bromodomain inhibitor, potentially resulting in inhibition of cell growth and apoptotic activity (Blood 2016 128:5104, PMID: 29941483, PMID: 31862959). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02983604 | Phase Ib/II | Exemestane Fulvestrant + GS-5829 Exemestane + GS-5829 Fulvestrant | GS-5829 in Combination With Fulvestrant or Exemestane in Women With Advanced Estrogen Receptor Positive, HER2 Negative-Breast Cancer | Terminated | USA | 0 |
| NCT02392611 | Phase I | Exemestane + GS-5829 | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GS-5829 in Adults With Advanced Solid Tumors and Lymphomas | Completed | USA | 0 |
| NCT02607228 | Phase Ib/II | Enzalutamide Exemestane + GS-5829 | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GS-5829 as a Single Agent and In Combination With Enzalutamide in Participants With Metastatic Castrate-Resistant Prostate Cancer | Terminated | USA | 0 |
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