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Therapy Name EZN-2968
Synonyms
Therapy Description

EZN-2968 is an antisense oligonucleotide that hybridizes with hypoxia-inducible factor-1alpha (HIF-1alpha) mRNA and inhibits HIF-1alpha protein expression, leading to tumor growth inhibition (PMID: 18974394, PMID: 25257607).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EZN-2968 SPC2968|RO7070179|EZN 2968|EZN2968|SPC 2968|SPC-2968|RO-7070179|RO 7070179 Antisense Therapy 14 EZN-2968 is an antisense oligonucleotide that hybridizes with hypoxia-inducible factor-1alpha (HIF-1alpha) mRNA and inhibits HIF-1alpha protein expression, leading to tumor growth inhibition (PMID: 18974394, PMID: 25257607).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02564614 Phase I EZN-2968 A Study of Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic Acid (mRNA) Antagonist (RO7070179), to Demonstrate Proof-of-mechanism in Adult Participants With Hepatocellular Carcinoma (HCC) Completed USA 0


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