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Therapy Name	SB590885
Synonyms
Therapy Description	SB590885 is a RAF kinase inhibitor with greater specificity for BRAF over CRAF and significant activity against BRAF V600E (PMID: 17145850, PMID: 32531927).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
SB590885			BRAF Inhibitor 26	SB590885 is a RAF kinase inhibitor with greater specificity for BRAF over CRAF and significant activity against BRAF V600E (PMID: 17145850, PMID: 32531927).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF V600E	melanoma	sensitive	SB590885	Preclinical - Cell culture	Actionable	In a preclinical study, SB590885 inhibited proliferation of melanoma cell lines harboring either monomeric BRAF V600E or dimeric isoform of V600E which conferred Zelboraf (vemurafenib)-resistance in culture (PMID: 27523909).	27523909
BRAF T529I BRAF V600E	Advanced Solid Tumor	predicted - resistant	SB590885	Preclinical	Actionable	In a preclinical study, transformed cells expressing BRAF V600E and the gatepkeeper mutation BRAF T529I were insensitive to SB590885-mediated inhibition of ERK signaling in culture (PMID: 20538618).	20538618
BRAF T529M BRAF V600E	Advanced Solid Tumor	predicted - resistant	SB590885	Preclinical	Actionable	In a preclinical study, transformed cells expressing BRAF V600E and the gatepkeeper mutation BRAF T529M were insensitive to SB590885-mediated inhibition of ERK signaling in culture (PMID: 20538618).	20538618
BRAF T529N BRAF V600E	Advanced Solid Tumor	resistant	SB590885	Preclinical	Actionable	In a preclinical study, transformed cells expressing BRAF V600E and the gatepkeeper mutation BRAF T529N were insensitive to SB590885 in culture (PMID: 20538618).	20538618
BRAF V600E	Advanced Solid Tumor	sensitive	SB590885	Preclinical	Actionable	In a preclinical study, SB590885 inhibited inhibited Erk phosphorylation and cell proliferation of transformed cells expression BRAF V600E in culture (PMID: 20538618).	20538618

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