Molecular Profile Detail

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Profile Name BRAF L505H BRAF V600E
Gene Variant Detail

BRAF L505H (gain of function)

BRAF V600E (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF L505H BRAF V600E melanoma predicted - resistant Vemurafenib Case Reports/Case Series Actionable In a clinical case study, a melanoma patient harboring BRAF V600E treated with Zelboraf (vemurafenib) subsequently demonstrated resistance likely due to the secondary resistance mutation, BRAF L505H (PMID: 25515853). 25515853
BRAF L505H BRAF V600E melanoma resistant U0126 Preclinical - Cell culture Actionable In a preclinical study, a melanoma cell line harboring BRAF V600E and expressing L505H was resistant to U0126 treatment in culture (PMID: 24112705). 24112705
BRAF L505H BRAF V600E melanoma resistant RAF265 Preclinical - Cell culture Actionable In a preclinical study, a melanoma cell line harboring BRAF V600E and expressing L505H was resistant to RAF265 treatment in culture (PMID: 24112705). 24112705
BRAF L505H BRAF V600E melanoma resistant SB590885 Preclinical - Cell culture Actionable In a preclinical study, a melanoma cell line harboring BRAF V600E and expressing L505H was resistant to SB590885 treatment in culture (PMID: 24112705). 24112705
BRAF L505H BRAF V600E Advanced Solid Tumor resistant PLX4720 Preclinical Actionable In a preclinical study, a cell line expressing BRAF V600E and L505H was resistant to PLX4720 treatment in culture and in a transplant mouse model (PMID: 24112705). 24112705
BRAF L505H BRAF V600E melanoma resistant PLX4720 Preclinical - Cell culture Actionable In a preclinical study, melanoma cell lines harboring BRAF V600E and expressing L505H were resistant to PLX4720 in culture (PMID: 24112705). 24112705
BRAF L505H BRAF V600E Advanced Solid Tumor resistant Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, a cell line expressing BRAF V600E and L505H was resistant to Zelboraf (vemurafenib) treatment in culture (PMID: 24112705). 24112705
BRAF L505H BRAF V600E Advanced Solid Tumor decreased response SB590885 Preclinical - Cell culture Actionable In a preclinical study, a cell line expressing BRAF V600E and L505H was less sensitive to SB590885 treatment compared to cells expressing BRAF V600E alone in culture (PMID: 24112705). 24112705
BRAF L505H BRAF V600E Advanced Solid Tumor decreased response GDC0879 Preclinical - Cell culture Actionable In a preclinical study, a cell line expressing BRAF V600E and L505H was less sensitive to GDC0879 treatment compared to cells expressing BRAF V600E alone in culture (PMID: 24112705). 24112705
BRAF L505H BRAF V600E Advanced Solid Tumor decreased response RAF265 Preclinical - Cell culture Actionable In a preclinical study, a cell line expressing BRAF V600E and L505H was less sensitive to RAF265 treatment compared to cells expressing BRAF V600E alone in culture (PMID: 24112705). 24112705