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Therapy Name Sotevtamab
Synonyms
Therapy Description

Sotevtamab is a monoclonal antibody that inhibits the activity of tumor associated human clusterin (sCLU), potentially decreasing epithelial-to-mesenchymal transition and reducing tumor growth (J Clin Oncol 42, 2024 (suppl 16; abstr 8577)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Sotevtamab AB 16B5|AB16B5|AB-16B5 Sotevtamab is a monoclonal antibody that inhibits the activity of tumor associated human clusterin (sCLU), potentially decreasing epithelial-to-mesenchymal transition and reducing tumor growth (J Clin Oncol 42, 2024 (suppl 16; abstr 8577)).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02412462 Phase I Sotevtamab Phase I Dose Escalation Study of AB-16B5 in Subjects With an Advanced Solid Malignancy Completed CAN 0


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