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Therapy Name AFM13
Synonyms
Therapy Description

AFM13 is a tetravalent bispecific antibody targeting CD30 and CD16A, which recruits CD16A-expressing NK cells to CD30-expressing tumor cells, potentially inducing tumor cell killing and enhanced antitumor immune response (PMID: 26231785, PMID: 33986022).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AFM13 AFM 13|AFM-13|Acimtamig AFM13 is a tetravalent bispecific antibody targeting CD30 and CD16A, which recruits CD16A-expressing NK cells to CD30-expressing tumor cells, potentially inducing tumor cell killing and enhanced antitumor immune response (PMID: 26231785, PMID: 33986022).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04101331 Phase II AFM13 Phase II Study to Assess AFM13 in Patients With R/R CD30-positive T-cell Lymphoma or Transformed Mycosis Fungoides (REDIRECT) Completed USA | TUR | POL | ITA | FRA | ESP | DEU | AUS 2
NCT03192202 Phase Ib/II AFM13 AFM13 in Relapsed/Refractory Cutaneous Lymphomas Completed USA 0
NCT04074746 Phase I Cyclophosphamide + Fludarabine AFM13 Modified Immune Cells (AFM13-NK) and A Monoclonal Antibody (AFM13) in Treating Patients With Recurrent or Refractory CD30 Positive Hodgkin or Non-Hodgkin Lymphomas Active, not recruiting USA 0


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