Therapy Detail
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| Therapy Name | BI 836826 + Idelalisib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BI 836826 | MAb 37.1|BI836826|BI-836826 | CD37 Antibody 9 | BI 836826 (MAb 37.1) is a monoclonal antibody that binds to CD37, resulting in anti-tumor immune response and tumor cell death (PMID: 26271483, PMID: 32172489). | |
| Idelalisib | Zydelig | CAL-101|GS-1101 | PIK3CD inhibitor 27 | Zydelig (idelalisib) inhibits PI3K-delta, preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival (PMID: 24450857). Zydelig (idelalisib) in combination with Rituxan (rituximab) is FDA-approved for use in patients with relapsed chronic lymphocytic leukemia (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02538614 | Phase Ib/II | BI 836826 + Idelalisib | Study of Idelalisib in Combination With BI 836826 in Participants With Chronic Lymphocytic Leukemia | Terminated | USA | 0 |
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