Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Idelalisib
Trade Name Zydelig
Synonyms CAL-101|GS-1101
Drug Descriptions

Zydelig (idelalisib) inhibits PI3K-delta, preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival (PMID: 24450857). Zydelig (idelalisib) is FDA approved for follicular B-cell non-Hodgkin lymphoma, relapsed small lymphocytic lymphoma, and in combination with Rituxan (rituximab) for relapsed chronic lymphocytic leukemia (FDA.gov).

DrugClasses PIK3CD inhibitor 27
CAS Registry Number 870281-82-6
NCIT ID C78825

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
BCL201 + Idelalisib BCL201 Idelalisib 0 1
Bendamustine + Idelalisib + Rituximab Bendamustine Idelalisib Rituximab 0 2
BI 836826 + Idelalisib BI 836826 Idelalisib 0 1
CA-4948 + Idelalisib CA-4948 Idelalisib 0 0
Entospletinib + Idelalisib Entospletinib Idelalisib 0 0
GSK2334470 + Idelalisib GSK2334470 Idelalisib 1 0
Idelalisib Idelalisib 4 11
Idelalisib + Lapatinib Idelalisib Lapatinib 0 0
Idelalisib + Loncastuximab tesirine-lpyl Idelalisib Loncastuximab tesirine-lpyl 0 0
Idelalisib + MK2206 Idelalisib MK2206 1 0
Idelalisib + Obinutuzumab Idelalisib Obinutuzumab 0 1
Idelalisib + Obinutuzumab + Tirabrutinib Idelalisib Obinutuzumab Tirabrutinib 0 1
Idelalisib + Ofatumumab Idelalisib Ofatumumab 0 1
Idelalisib + Otlertuzumab + Rituximab Idelalisib Otlertuzumab Rituximab 0 1
Idelalisib + Pembrolizumab Idelalisib Pembrolizumab 0 1
Idelalisib + Ricolinostat Idelalisib Ricolinostat 0 1
Idelalisib + Rituximab Idelalisib Rituximab 3 3
Idelalisib + Rituximab + Venetoclax Idelalisib Rituximab Venetoclax 0 1
Idelalisib + Tafasitamab-cxix Idelalisib Tafasitamab-cxix 0 1
Idelalisib + Tazemetostat Idelalisib Tazemetostat 0 0
Idelalisib + Tirabrutinib Idelalisib Tirabrutinib 0 1


Additional content available in CKB BOOST