Therapy Detail
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| Therapy Name | DNX-2401 + Interferon gamma |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DNX-2401 | Ad5-Delta24RGD|DNX2401 | DNX-2401 is an adenovirus that replicates in Rb1/p16-deficient cells, resulting in lysis of tumor cells (PMID: 29432077). | ||
| Interferon gamma | Actimmune | gamma interferon|IFN-G|recombinant interferon gamma | Interferon gamma is a cytokine that binds IFN-gamma receptors, leading to pleiotropic effects, including stimulating antibody-dependent cytotoxicity and enhanced natural killer cell activity against tumor cells and the activation of caspases, leading to apoptosis of malignant cells (PMID: 14525967). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02197169 | Phase I | DNX-2401 DNX-2401 + Interferon gamma | DNX-2401 With Interferon Gamma (IFN-gamma) for Recurrent Glioblastoma or Gliosarcoma Brain Tumors (TARGET-I) | Completed | USA | 0 |
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