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Therapy Name Pembrolizumab + PGG beta-glucan
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PGG beta-glucan Imprime PGG|Odetiglucan Imprime PGG (PGG beta-glucan) binds to and promotes cytotoxicity of neutrophils bound to tumor cells via complement receptor 3 (CR3) (NCI Drug Dictionary).
Pembrolizumab Keytruda MK-3475 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, PMBL, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous SCC, MSI-H or dMMR or TMB high advanced solid tumors, NSCLC and CD274 (PD-L1)-positive NSCLC, esophageal SCC, cervical cancer, HNSCC, and TNBC, in combination with platnum-based chemo in NSCLC, with pemetrexed and platinum in pleural mesothelioma and non-sNSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in sNSCLC, with axitinib or lenvatinib in RCC, with lenvatinib in endometrial carcinoma that is not MSI-H or dMMR, in combination with platinum and fluoropyrimidine-based chemo for esophageal or gastroesophageal carcinoma, in combination with Herceptin (trastuzumab), fluoropyrimidine- and platinum-containing chemo for CD274 (PD-L1)-positive, HER2-positive gastric or GEJ adenocarcinoma, in combination with fluoropyrimidine- and platinum-containing chemo for HER2-negative gastric or GEJ adenocarcinoma, in combination with platinum-based chemotherapy, with or without bevacizumab, for patients with CD274 (PD-L1)-positive (CPS>=1) cervical cancer, in combination with gemcitabine and cisplatin for biliary tract cancer, in combination with chemoradiation for cervical cancer, and in combination with carboplatin and paclitaxel for endometrial carcinoma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05159778 Phase II Pembrolizumab + PGG beta-glucan Phase 2 Study of Imprime PGG and Pembrolizumab in Patients With HR+/HER2- Metastatic Breast Cancer (mBCA) Completed USA 0
NCT04995094 Phase II Pembrolizumab Pembrolizumab + PGG beta-glucan Study of Neoadjuvant Imprime PGG and Pembrolizumab for Stage III, Resectable Melanoma Withdrawn USA 0
NCT03246685 Phase II Pembrolizumab + PGG beta-glucan Phase 2 Study of Imprime PGG & Pembrolizumab in Subjects With Adv SCCHN Who Failed Pembro Monotherapy or Experiencing SD Terminated USA 0
NCT02981303 Phase II Pembrolizumab + PGG beta-glucan Study of Imprime PGG and Pembrolizumab in Advanced Melanoma and Triple Negative Breast Cancer Completed USA 0
NCT03003468 Phase Ib/II Pembrolizumab + PGG beta-glucan Pembrolizumab + Imprime PGG for Metastatic Non-small Cell Lung Cancer After Progression on First-Line Therapy: Big Ten Cancer Research Consortium BTCRC-LUN15-017 Completed USA 0
NCT07082439 Phase II Pembrolizumab + PGG beta-glucan Pembrolizumab and Odetiglucan in Liver Predominant Metastatic Colorectal Adenocarcinoma Recruiting USA 0


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