Therapy Detail
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| Therapy Name | PLX7486 + unspecified CTLA4 antibody |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| PLX7486 | PLX 7486|PLX-7486 | CSF1R Inhibitor 28 Trk Receptor Inhibitor (Pan) 33 | PLX7486 binds to and inhibits CSF1R, TRKA, TRKB, and TRKC, which potentially results in decreased tumor cell proliferation (PMID: 28174090). | |
| unspecified CTLA4 antibody | experimental CTLA4 antibody | Immune Checkpoint Inhibitor 150 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 positive | colon adenocarcinoma | predicted - sensitive | PLX7486 + unspecified CTLA4 antibody | Preclinical - Cell line xenograft | Actionable | In a preclinical study, combination of PLX7486 and anti-CTLA4 immunotherapy resulted in enhanced anti-tumor effect compared to single therapy in animal models of Ntrk-positive colon adenocarcinoma (Cancer Immunol Res 2017;5(3 Suppl): Abstract nr PR01). | detail... |
| NTRK1 positive | melanoma | predicted - sensitive | PLX7486 + unspecified CTLA4 antibody | Preclinical - Cell line xenograft | Actionable | In a preclinical study, combination of PLX7486 and anti-CTLA4 immunotherapy resulted in enhanced anti-tumor effect compared to single therapy in animal models of Ntrk-positive melanoma (Cancer Immunol Res 2017;5(3 Suppl): Abstract nr PR01). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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