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Therapy Name RVU120
Synonyms
Therapy Description

RVU120 (SEL120) selectively inhibits CDK8, resulting in decreased STAT5 and STAT1 phosphorylation and downstream signaling, and potentially leading to reduced tumor cell growth (PMID: 28422713).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
RVU120 SEL120|SEL 120-34|SEL120-34A|RVU 120|RVU-120 CDK8 Inhibitor 5 RVU120 (SEL120) selectively inhibits CDK8, resulting in decreased STAT5 and STAT1 phosphorylation and downstream signaling, and potentially leading to reduced tumor cell growth (PMID: 28422713).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06268574 Phase II RVU120 Safety and Efficacy of RVU120 for Treatment of Relapsed/Refractory AML (RIVER-52) Active, not recruiting POL | ITA | FRA | ESP 0
NCT05052255 Phase Ib/II RVU120 RVU120 (SEL120) in Patients With Relapse/Refractory Metastatic or Advanced Solid Tumors Active, not recruiting POL | ESP 0
NCT04021368 Phase I RVU120 SEL120 in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome Active, not recruiting USA | POL 0


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