Therapy Detail
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| Therapy Name | RXDX-106 |
| Synonyms | |
| Therapy Description |
RXDX-106 (CEP-40783) is a small molecule inhibitor of TAM family kinases (Axl, Mertk, and Tyro3) and Met that promotes anti-tumor immune response, resulting in tumor growth inhibition (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31, PMID: 30501104, PMID: 30723115). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| RXDX-106 | CEP-40783|CEP40783|CEP 40783|RXDX106|RXDX 106 | AXL Inhibitor 30 MERTK Inhibitor 13 MET Inhibitor 59 TYRO3 Inhibitor 7 | RXDX-106 (CEP-40783) is a small molecule inhibitor of TAM family kinases (Axl, Mertk, and Tyro3) and Met that promotes anti-tumor immune response, resulting in tumor growth inhibition (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31, PMID: 30501104, PMID: 30723115). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TYRO3 over exp | Advanced Solid Tumor | sensitive | RXDX-106 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells overexpressing Tyro3 in culture, resulting in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31). | detail... |
| MERTK over exp | gastric adenocarcinoma | sensitive | RXDX-106 | Preclinical - Patient cell culture | Actionable | In a preclinical study, RXDX-106 inhibited proliferation of patient derived gastric cancer cells overexpressing Mertk (PMID: 29285287). | 29285287 |
| AXL over exp | Advanced Solid Tumor | sensitive | RXDX-106 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells over expressing Axl in culture, resulted in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31). | detail... |
| MERTK over exp | Advanced Solid Tumor | sensitive | RXDX-106 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells overexpressing Mertk in culture and resulted in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31). | detail... |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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