Therapy Detail
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| Therapy Name | Lenalidomide + Tafasitamab-cxix |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Lenalidomide | Revlimid | IMiD-1 | Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov). | |
| Tafasitamab-cxix | Monjuvi | MOR00208|XmAb5574|MOR-208|MOR208|Tafasitamab | CD19 Antibody 21 | Monjuvi (tafasitamab-cxix) is an CD19-targeted antibody with an engineered Fc region, which may result in an increased antibody-dependent cell-mediated cytotoxicity response against CD19-expressing tumor cells (PMID: 23277329, PMID: 32511983). Monjuvi (tafasitamab-cxix) is FDA approved for use in combination with Revlimid (lenalidomide) in patients with relapsed or refractory diffuse large B cell lymphoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05890352 | Phase II | Lenalidomide + Tafasitamab-cxix Lenalidomide + Tafasitamab-cxix + Tazemetostat Lenalidomide + Tafasitamab-cxix + Zanubrutinib | Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment | Recruiting | USA | 0 |
| NCT05429268 | Phase III | Lenalidomide + Tafasitamab-cxix | Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND) | Recruiting | TUR | ROU | POL | NOR | ISR | IRL | HUN | HRV | GBR | FIN | DNK | CZE | BGR | 1 |
| NCT04882163 | Phase Ib/II | Cisplatin + Dexamethasone + Gemcitabine + Iberdomide + Rituximab Lenalidomide + Tafasitamab-cxix Iberdomide + Polatuzumab vedotin-piiq + Rituximab Iberdomide + Tafasitamab-cxix Bendamustine + Polatuzumab vedotin-piiq + Rituximab | Study to Evaluate Tolerability of Iberdomide (CC-220) in Combination With Polatuzumab Vedotin Plus Rituximab or Tafasitamab or Rituximab Plus Chemotherapy in B-cell Lymphoma | Withdrawn | USA | GBR | FRA | ESP | BEL | AUT | 2 |
| NCT05222555 | Phase Ib/II | Lenalidomide + Tafasitamab-cxix | Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients (MINDway) | Active, not recruiting | USA | POL | ITA | ISR | FRA | ESP | CZE | AUT | 1 |
| NCT05328102 | Phase II | Lenalidomide + Tafasitamab-cxix Lenalidomide + Tafasitamab-cxix + XmAb13676 | Phase 2 Study of Plamotamab Combined With Tafasitamab Plus Lenalidomide Versus Tafasitamab Plus Lenalidomide in R/R DLBCL | Terminated | USA | FRA | ESP | 0 |
| NCT05788289 | Phase II | Lenalidomide + Tafasitamab-cxix | A Study of Tafasitamab and Lenalidomide in People With Mantle Cell Lymphoma | Terminated | USA | 0 |
| NCT02399085 | Phase II | Lenalidomide + Tafasitamab-cxix | A Study to Evaluate the Safety and Efficacy of Lenalidomide With MOR00208 in Patients With R-R DLBCL | Completed | USA | POL | ITA | HUN | GBR | FRA | ESP | DEU | CZE | BEL | 0 |
| NCT05351593 | Phase Ib/II | Lenalidomide + Tafasitamab-cxix | Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma | Recruiting | USA | 0 |
| NCT02005289 | Phase II | Lenalidomide + Tafasitamab-cxix Ibrutinib + Tafasitamab-cxix | Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL | Active, not recruiting | USA | 0 |
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