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Therapy Name | Bortezomib + Dexamethasone + Radium Ra 223 dichloride |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Bortezomib | Velcade | Velcade (bortezomib) is a reversible proteasome inhibitor that inhibits survival of malignant cells and regulates bone remodeling (PMID: 26579531). Velcade (bortezomib) is FDA approved for the treatment of mantle cell lymphoma and multiple myeloma (FDA.gov). | ||
Dexamethasone | Adexone | Desametasone | ||
Radium Ra 223 dichloride | Xofigo | BAY 88-8223|alpharadin|BAY88-8223|Radium 223 Dichloride | Radium Ra 223 dichloride is a radium-based radiopharmaceutical that targets bone via incorporation into bony matrix, and results in DNA double strand breaks and tumor regression in bone (NCI Drug Dictionary). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT02928029 | Phase Ib/II | Bortezomib + Dexamethasone + Radium Ra 223 dichloride | Study Testing Radium-223 Dichloride in Relapsed Multiple Myeloma | Terminated | USA | ESP | 1 |