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| Drug Name | Tegavivint |
| Trade Name | |
| Synonyms | BC-2059|BC 2059|Tegatrabetan|BC2059 |
| Drug Descriptions |
Tegavivint (BC2059) binds to beta-catenin (CTNNB1) and interferes with binding to TBL1 and TBLR1, resulting in increased degradation of beta-catenin and potentially leading to increased apoptosis of tumor cells with activated canonical Wnt signaling (PMID: 28500235, PMID: 30793158). |
| DrugClasses | CTNNB1 Inhibitor 27 |
| CAS Registry Number | 1227637-23-1 |
| NCIT ID | C155885 |
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Birabresib + Tegavivint | Birabresib Tegavivint | 0 | 0 |
| Birabresib + Tegavivint + Venetoclax | Birabresib Tegavivint Venetoclax | 0 | 0 |
| Bortezomib + Tegavivint | Bortezomib Tegavivint | 0 | 0 |
| Cabozantinib + Tegavivint | Cabozantinib Tegavivint | 0 | 1 |
| Decitabine + Tegavivint | Decitabine Tegavivint | 0 | 1 |
| Gemcitabine + Tegavivint | Gemcitabine Tegavivint | 0 | 1 |
| GNE-049 + Tegavivint | GNE-049 Tegavivint | 0 | 0 |
| Lenvatinib + Tegavivint | Lenvatinib Tegavivint | 0 | 1 |
| Osimertinib + Tegavivint | Osimertinib Tegavivint | 0 | 1 |
| Pembrolizumab + Tegavivint | Pembrolizumab Tegavivint | 0 | 0 |
| Tegavivint | Tegavivint | 1 | 4 |
| Tegavivint + Venetoclax | Tegavivint Venetoclax | 0 | 0 |