Therapy Detail
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| Therapy Name | Sotrastaurin |
| Synonyms | |
| Therapy Description |
Sotrastaurin (AEB071) is a pan-PKC inhibitor, which induces cell cycle arrest and apoptosis (PMID: 19491325, PMID: 31261030). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Sotrastaurin | AEB071 | PKC Inhibitor (Pan) 11 | Sotrastaurin (AEB071) is a pan-PKC inhibitor, which induces cell cycle arrest and apoptosis (PMID: 19491325, PMID: 31261030). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02285244 | Phase II | Sotrastaurin | Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation | Withdrawn | 0 | |
| NCT01430416 | Phase I | Sotrastaurin | Safety and Efficacy of AEB071 in Metastatic Uveal Melanoma Patients | Completed | USA | NLD | GBR | FRA | 0 |
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