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Therapy Name mRNA-2416
Synonyms
Therapy Description

mRNA-2416 is a lipid nanoparticle-encapsulated mRNA encoding the ligand, TNFSF4 (OX40L, CD252), which upon translation binds to TNFRSF4 (OX40, CD134) expressed on T-lymphocytes, potentially leading to proliferation of T-cells and enhanced anti-tumor response (Cancer Res 2020;80(16 Suppl):Abstract nr CT032, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
mRNA-2416 mRNA 2416 mRNA-2416 is a lipid nanoparticle-encapsulated mRNA encoding the ligand, TNFSF4 (OX40L, CD252), which upon translation binds to TNFRSF4 (OX40, CD134) expressed on T-lymphocytes, potentially leading to proliferation of T-cells and enhanced anti-tumor response (Cancer Res 2020;80(16 Suppl):Abstract nr CT032, NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03323398 Phase I mRNA-2416 Dose Escalation Study of mRNA 2416 for Intratumoral Injection to Patients With Advanced Malignancies Terminated USA 0


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