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Therapy Name	AZD8330
Synonyms
Therapy Description	AZD8330 is a MEK1/2 inhibitor, which blocks signaling of the Ras/Raf/MEK/ERK pathway to prevent cell proliferation (PMID: 24434059, PMID: 30039885).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AZD8330		ARRY-424704\|ARRY-704\|AZD-8330	MEK inhibitor (Pan) 27 MEK1 Inhibitor 27 MEK2 Inhibitor 25	AZD8330 is a MEK1/2 inhibitor, which blocks signaling of the Ras/Raf/MEK/ERK pathway to prevent cell proliferation (PMID: 24434059, PMID: 30039885).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
MAP2K1 C121S	Advanced Solid Tumor	resistant	AZD8330	Preclinical - Cell culture	Actionable	In a preclinical study, Map2k1 C121S displayed resistance to the Mek inhibitor, AZD8330, as demonstrated by constitutive activation of Map2k1 in transformed human kidney cells (PMID: 29753091).	29753091
MAP2K1 F129L	Advanced Solid Tumor	resistant	AZD8330	Preclinical - Cell culture	Actionable	In a preclinical study, Map2k1 F129L displayed resistance to the Mek inhibitor, AZD8330, as demonstrated by constitutive activation of Map2k1 in transformed human kidney cells (PMID: 29753091).	29753091
MAP2K1 F53L	Advanced Solid Tumor	resistant	AZD8330	Preclinical - Cell culture	Actionable	In a preclinical study, Map2k1 F53L displayed resistance to the Mek inhibitor, AZD8330, as demonstrated by constitutive activation of Map2k1 in transformed human kidney cells (PMID: 29753091).	29753091
MAP2K1 I111S	Advanced Solid Tumor	resistant	AZD8330	Preclinical - Cell culture	Actionable	In a preclinical study, Map2k1 I111S displayed resistance to the Mek inhibitor, AZD8330, as demonstrated by constitutive activation of Map2k1 in transformed human kidney cells (PMID: 29753091).	29753091
MAP2K1 K57N	Advanced Solid Tumor	resistant	AZD8330	Preclinical - Cell culture	Actionable	In a preclinical study, Map2k1 K57N displayed resistance to the Mek inhibitor, AZD8330, as demonstrated by constitutive activation of Map2k1 in transformed human kidney cells (PMID: 29753091).	29753091
MAP2K1 Q56P	Advanced Solid Tumor	resistant	AZD8330	Preclinical - Cell culture	Actionable	In a preclinical study, Map2k1 Q56P displayed resistance to the Mek inhibitor, AZD8330, as demonstrated by constitutive activation of Map2k1 in transformed human kidney cells (PMID: 29753091).	29753091
MAP2K1 V211D	Advanced Solid Tumor	resistant	AZD8330	Preclinical - Cell culture	Actionable	In a preclinical study, Map2k1 V211D displayed resistance to the Mek inhibitor, AZD8330, as demonstrated by constitutive activation of Map2k1 in transformed human kidney cells (PMID: 29753091).	29753091

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