Therapy Detail
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| Therapy Name | BMS-986253 |
| Synonyms | |
| Therapy Description |
BMS-986253 (HuMax-IL8) is a monoclonal antibody that targets interleukin-8 (CXCL8, IL8) to prevent activation of the receptors, CXCR1 and CXCR2, in effort to prevent immune escape and tumor progression (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3091-3091). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BMS-986253 | HuMax-IL8|MDX 018|MDX-018|BMS986253|BMS- 86253 | BMS-986253 (HuMax-IL8) is a monoclonal antibody that targets interleukin-8 (CXCL8, IL8) to prevent activation of the receptors, CXCR1 and CXCR2, in effort to prevent immune escape and tumor progression (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3091-3091). |
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04347226 | Phase II | BMS-986253 | Anti-Interleukin-8 (Anti-IL-8) for Cancer Patients With COVID-19 | Terminated | USA | 0 |
| NCT05148234 | Phase Ib/II | BMS-986253 + Decitabine and Cedazuridine BMS-986253 | A Phase I/II Trial of BMS-986253 in Myelodysplastic Syndromes | Terminated | USA | 0 |
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