Therapy Detail
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| Therapy Name | SGN-CD123A |
| Synonyms | |
| Therapy Description |
SGN-CD123A is an antibody-drug conjugate comprising a CD123 (IL3RA)-targeted antibody linked to pyrrolobenzodiazepine dimers, which delivers the DNA cross-linking agent to CD123 (IL3RA)-expressing tumor cells, potentially resulting in increased tumor cell death and decreased tumor growth (PMID: 29142066). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SGN-CD123A | SGNCD123A|SGN CD123A | CD123 (IL3RA) Antibody 14 | SGN-CD123A is an antibody-drug conjugate comprising a CD123 (IL3RA)-targeted antibody linked to pyrrolobenzodiazepine dimers, which delivers the DNA cross-linking agent to CD123 (IL3RA)-expressing tumor cells, potentially resulting in increased tumor cell death and decreased tumor growth (PMID: 29142066). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02848248 | Phase I | SGN-CD123A | A Safety Study of SGN-CD123A in Patients With Acute Myeloid Leukemia | Terminated | USA | 0 |
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