Therapy Detail
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| Therapy Name | ML309 |
| Synonyms | |
| Therapy Description |
ML309 inhibits mutant IDH1, resulting in decreased 2HG production and potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 24668804, PMID: 28986582). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ML309 | IDH1 Inhibitor 8 | ML309 inhibits mutant IDH1, resulting in decreased 2HG production and potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 24668804, PMID: 28986582). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H | Advanced Solid Tumor | predicted - sensitive | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 inhibited the activity of IDH1 R132H in an in vitro assay (PMID: 30249606). | 30249606 |
| IDH1 R132S | Advanced Solid Tumor | predicted - sensitive | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 inhibited the activity of IDH1 R132S in an in vitro assay (PMID: 30249606). | 30249606 |
| IDH1 R132Q | Advanced Solid Tumor | predicted - resistant | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 treatment did not inhibit the activity of IDH1 R132Q in an in vitro assay (PMID: 30249606). | 30249606 |
| IDH1 R132L | Advanced Solid Tumor | predicted - sensitive | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 inhibited the activity of IDH1 R132L in an in vitro assay (PMID: 30249606). | 30249606 |
| IDH1 R132V | Advanced Solid Tumor | predicted - sensitive | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 inhibited the activity of IDH1 R132V in an in vitro assay (PMID: 30249606). | 30249606 |
| IDH1 R132G | Advanced Solid Tumor | predicted - sensitive | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 inhibited the activity of IDH1 R132G in an in vitro assay (PMID: 30249606). | 30249606 |
| IDH1 R132C | Advanced Solid Tumor | predicted - sensitive | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 inhibited the activity of IDH1 R132C in an in vitro assay (PMID: 30249606). | 30249606 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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