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| Profile Name | IDH1 R132V |
| Gene Variant Detail | |
| Relevant Treatment Approaches | IDH Inhibitor (Pan) IDH1 Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| IDH1 R132V | Advanced Solid Tumor | predicted - sensitive | IDH1 Inhibitor | ML309 | Preclinical - Biochemical | Actionable | In a preclinical study, ML309 inhibited the activity of IDH1 R132V in an in vitro assay (PMID: 30249606). | 30249606 |
| IDH1 R132V | Advanced Solid Tumor | predicted - sensitive | IDH1 Inhibitor | AGI-5198 | Preclinical - Biochemical | Actionable | In a preclinical study, AGI-5198 inhibited the activity of IDH1 R132V in an in vitro assay (PMID: 30249606). | 30249606 |