Therapy Detail
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| Therapy Name | CPI-1205 + Enzalutamide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CPI-1205 | EZH2 inhibitor 20 | CPI-1205 inhibits EZH2, including both wild-type and mutant forms, potentially resulting in decreased tumor growth (PMID: 27739677, PMID: 29905573). | ||
| Enzalutamide | Xtandi | MDV3100|ASP9785 | Hormone - Anti-androgens 57 | Xtandi (enzalutamide) is a second-generation small molecule inhibitor of androgen receptor, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA-approved for use in patients with castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03480646 | Phase Ib/II | Enzalutamide Abiraterone + CPI-1205 + Prednisone CPI-1205 + Enzalutamide | ProSTAR: A Study Evaluating CPI-1205 in Patients With Metastatic Castration Resistant Prostate Cancer | Completed | USA | 0 |
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