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Therapy Name DHES0815A
Synonyms
Therapy Description

DHES0815A is an antibody-drug conjugate (ADC) comprising an anti-ERBB2 (HER2) antibody linked to PBD-MA, which delivers the DNA-crosslinking agent to ERBB2 (HER2)-expressing tumor cells, potentially resulting in increased cell death (PMID: 30841523).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DHES0815A DHES-0815A HER2 (ERBB2) Antibody 76 HER2 (ERBB2) Antibody-Drug Conjugate 31 DHES0815A is an antibody-drug conjugate (ADC) comprising an anti-ERBB2 (HER2) antibody linked to PBD-MA, which delivers the DNA-crosslinking agent to ERBB2 (HER2)-expressing tumor cells, potentially resulting in increased cell death (PMID: 30841523).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03451162 Phase I DHES0815A Safety, Tolerability, and Pharmacokinetic (PK) Study of DHES0815A in Participants With Human Epidermal Growth Factor Receptor (HER)2-Positive Breast Cancer Completed USA 1


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