Therapy Detail
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| Therapy Name | BMS-986178 + Nelitolimod |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BMS-986178 | BMS986178|BMS 986178 | OX40 Antibody 15 | BMS-986178 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (PMID: 33148673). | |
| Nelitolimod | SD101|SD 101|SD-101 | TLR9 Agonist 9 | Nelitolimod (SD-101) is an oligonucleotide which interacts with Toll-Like Receptor 9 (TLR9) and activates memory T helper cells 1 (Th1) (PMID: 30154193, PMID: 31921384). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03410901 | Phase I | BMS-986178 + Nelitolimod | TLR9 Agonist SD-101, Anti-OX40 Antibody BMS 986178, and Radiation Therapy in Treating Patients With Low-Grade B-Cell Non-Hodgkin Lymphomas | Completed | USA | 0 |
| NCT03831295 | Phase I | BMS-986178 + Nelitolimod | SD-101 and BMS-986178 in Treating Patients With Advanced or Metastatic Solid Malignancies | Completed | USA | 0 |
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