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Therapy Name	TNO155
Synonyms
Therapy Description	TNO155 is an inhibitor of PTPN11 (SHP2), which potentially blocks SHP2 signaling, thereby inhibiting activation of the MAPK pathway and subsequent tumor cell growth (PMID: 38032104, Cancer Res (2022) 82 (12_Supplement): 1054).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
TNO155		TNO-155\|TNO 155	SHP2 Inhibitor 20	TNO155 is an inhibitor of PTPN11 (SHP2), which potentially blocks SHP2 signaling, thereby inhibiting activation of the MAPK pathway and subsequent tumor cell growth (PMID: 38032104, Cancer Res (2022) 82 (12_Supplement): 1054).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ALK F1174L	neuroblastoma	sensitive	TNO155	Preclinical - Cell line xenograft	Actionable	In a preclinical study, TNO155 decreased viability and invasion of neuroblastoma cell lines harboring ALK F1174L in culture and decreased tumor growth and cell invasion and increased survival in cell line xenograft models (PMID: 38032104).	38032104
ALK R1275Q	neuroblastoma	sensitive	TNO155	Preclinical - Cell culture	Actionable	In a preclinical study, TNO155 decreased viability of neuroblastoma cell lines harboring ALK R1275Q in culture (PMID: 38032104).	38032104
ROS1 D2113G	Advanced Solid Tumor	sensitive	TNO155	Preclinical - Cell culture	Actionable	In a preclinical study, TNO155 inhibited proliferation of transformed cells expressing ROS1 D2113G in culture (PMID: 37587872).	37587872
ROS1 D2113N	Advanced Solid Tumor	sensitive	TNO155	Preclinical - Cell culture	Actionable	In a preclinical study, TNO155 inhibited proliferation of transformed cells expressing ROS1 D2113N in culture (PMID: 37587872).	37587872

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03114319	Phase I	TNO155	Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors	Active, not recruiting	USA \| NLD \| ITA \| ESP \| CAN	4

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