Therapy Detail
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| Therapy Name | IDE196 |
| Synonyms | |
| Therapy Description |
IDE196 (LXS196) is an inhibitor of protein kinase C (PKC), thereby blocking signaling pathways triggered by PKC, which may result in cell cycle arrest and apoptosis (AACR Annual Meeting 2019, Abstract CT068). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| IDE196 | LXS196|IDE 196|IDE-196|Darovasertib | PKC Inhibitor (Pan) 11 | IDE196 (LXS196) is an inhibitor of protein kinase C (PKC), thereby blocking signaling pathways triggered by PKC, which may result in cell cycle arrest and apoptosis (AACR Annual Meeting 2019, Abstract CT068). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05187884 | Phase II | IDE196 | Neoadjuvant/Adjuvant Trial of Darovasertib in Ocular Melanoma (NADOM) | Active, not recruiting | AUS | 0 |
| NCT02601378 | Phase I | IDE196 + Siremadlin IDE196 | A Phase I Study of LXS196 in Patients With Metastatic Uveal Melanoma. | Terminated | USA | NOR | NLD | FRA | ESP | AUS | 0 |
| NCT05907954 | Phase II | IDE196 | (Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma | Recruiting | USA | NLD | ITA | GBR | FRA | DEU | CAN | AUS | 0 |
| NCT03947385 | Phase Ib/II | IDE196 | Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions | Recruiting | USA | CAN | AUS | 0 |
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